SYN-JEM: A Quantitative Job-Exposure Matrix for Five Lung Carcinogens

Sensitivity analyses of exposure estimates from a quantitative job-exposure matrix (SYN-JEM) for use in community-based studies.

OBJECTIVES We describe the elaboration and sensitivity analyses of a quantitative job-exposure matrix (SYN-JEM) for respirable crystalline silica (RCS). The aim was to gain insight into the robustness of the SYN-JEM RCS estimates based on critical decisions taken in the elaboration process. METHODS SYN-JEM for RCS exposure consists of three axes (job, region, and year) based on estimates deri...

Development of an exposure measurement database on five lung carcinogens (ExpoSYN) for quantitative retrospective occupational exposure assessment.

BACKGROUND SYNERGY is a large pooled analysis of case-control studies on the joint effects of occupational carcinogens and smoking in the development of lung cancer. A quantitative job-exposure matrix (JEM) will be developed to assign exposures to five major lung carcinogens [asbestos, chromium, nickel, polycyclic aromatic hydrocarbons (PAH), and respirable crystalline silica (RCS)]. We assembl...

Application of a job-exposure matrix to national mortality statistics for lung cancer.

Validation of a semi-quantitative job exposure matrix at a Söderberg aluminum smelter.

OBJECTIVES We tested the validity of a job exposure matrix (JEM) for coal tar pitch volatiles (CTPV) at a Söderberg aluminum smelter. The JEM had been developed by a committee of company hygienists and union representatives for an earlier study of cancer incidence and mortality. Our aim was to test the validity and reliability of the expert-based assignments. METHODS Personal CTPV exposure me...

A job-exposure matrix for occupational noise: development and validation.

OBJECTIVE To develop a job-exposure matrix (JEM) for occupational noise in Sweden and to estimate its validity. METHODS The JEM, developed by a group of experienced occupational hygienists, contains 321 job families with information regarding occupational noise from 1970 to 2004. The occupational noise information derives from measurements collected from different sources. The time period lab...